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Active GLP-1R interacts with the PKA-RI-recruiting AKAP SPHKAP at ERMCSs via VAPB Amongst the interactors enriched for active GLP-1R binding in our MS interactome analysis, we identified both PKA-RI/ and the A-kinase anchoring protein (AKAP) SPHKAP, a paralog of AKAP11 (also known as AKAP220) that binds to two RI subunits of the PKA holoenzyme 29

Induction of C-X-C chemokine receptor type 7 (CXCR7) switches stromal cell-derived factor-1 (SDF-1) signaling and phagocytic activity in macrophages linked to atherosclerosis

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This helps control cravings and manage food intake, ultimately contributing to weight loss over time