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(2026) Authors contributions Contributed substantially to the conception, design, literature review, analysis, and writing of this manuscript: Elangovan S, Cheah CCM, Goh GBB Reviewed and approved the final version of the manuscript prior to submission: Elangovan S, Cheah CCM, Goh GBB Availability of data and materials Not applicable

Challenges and Future Research Directions Despite the demonstrated efficacy of GLP-1based therapies, several challenges limit their widespread application in adolescent populations