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As noted earlier, many of these early model studies that suggested the importance of Fc-dependent effector functions also found that protection was independent of complement, leading to a greater focus on FcR-mediated interactions 87

Success requires physician supervision, objective body composition monitoring (not just scale weight), and integration with proper nutrition and exercise foundations for optimal metabolic outcomes

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Some research also suggests that GLP-1 therapies may indirectly reduce androgen levels by improving insulin sensitivity, which is a key driver of hormonal imbalance in PCOS 10 11