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The data show that patients achieved a median %TWL of 25.5% (IQR 20.431.6) and %EWL of 66.3% (IQR 44.6116.3) after 1 year of arGLP-1 treatment, compared to 16.6% (IQR 10.524.5) and 40.8% (IQR 27.952.7) at the initiation of therapy
10.1161/CIRCHEARTFAILURE.123.011246 178 KarnesJ
This kinase activation can initiate intracellular signalling cascades via PI3K/Akt/mTOR or Ras/Raf/MEK/ERK pathways that affect the transcriptional programs associated with cell proliferation, differentiation, protein translation and cellular metabolism (substrate transport) as well as apoptosis
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