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One candidate mechanism underlying this neuroprotective effect lies in the ability of metformin to improve insulin sensitivity, reduce chronic inflammation, and exert direct effects on brain cells [24]

GLP-1 receptor activation in the hypothalamus and ovary affects reproductive hormone secretion

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Deferiprone (10 mg/kg) dramatically reduced the loss of dopaminergic neurons and striatal dopamine content in the 6-OHDA rat model of PD (Dexter et al., 2011)