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Among the numerous partners that interact with NRF2 regulating its activity, two members of the CNC-bZIP protein family BTB and CNC homolog 1 (BACH1) and BTB and CNC homolog 2 (BACH2) are two negative regulators of NRF2: they compete with NRF2 for the binding to ARE sequences of target genes, thereby preventing the production of antioxidant enzymes and cellular defense against toxicity [232, 233]
Cureus 16(4):e57636 Schuurman AR, Reijnders TD, van Engelen TS, Lopold V, de Brabander J, van Linge C, Schinkel M, Pereverzeva L, Haak BW, Brands X (2022) The host response in different aetiologies of community-acquired pneumonia
acnes), can contribute to pore blockage and inflammation visible as redness, swelling and pus that may accompany acne spots
As with any medication, potential side effects, drug interactions, and contraindications must be reviewed
