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174 Interestingly, some emerging evidence suggests protein restriction may not be as important for patients being treated with RAAS inhibitors and SGLT2 inhibitors, and several leading guidelines do not recommend any protein restriction for people with CKD, although excess protein intake is often discouraged

Findings In total, 99 individuals were recruited and invited to complete the three-day food record

Furthermore, the systemic administration of high-dose epigenetic modulators carries the risk of pleiotropic effects, potentially altering the expression of non-target genes in other tissues, which necessitates the development of heart-targeted delivery mechanisms

Cardiac-specific elision of Fth1 (encoding ferritin heavy chain) causes iron dysregulation and increased oxidative stress in the heart, leading to increased sensitivity to ferroptosis induced by iron overload [76]