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For example, the SELECT trial showed a 20% improvement in major cardiovascular events (i.e., heart attacks, strokes, and deaths from those cases) in adults on weekly semaglutide who were overweight or obese (without diabetes) and with preexisting cardiovascular disease, as well as an improvement in all-cause mortality of 19%

Opportunities for Reduction of Residual Risk in Type 2 Diabetes Type 2 diabetes (T2D) remains one of the most potent accelerators of cardiovascular disease (CVD), even as therapeutic strategies have evolved beyond glycemic control alone

No trials specifically enrolled elderly individuals, those with significant cardiovascular disease, individuals with active cancer, or pregnant/breastfeeding women