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In the context of a potential therapy for NASH, stabilization against FAP degradation is noteworthy because expression of FAP is greatly elevated in liver from NASH patients compared to appropriate control liver (297)
Oxidative stress is a major hallmark of skin aging that may lead to DNA damage, mitochondrial dysfunction, and inflammation at the cellular levelall of which contribute to aging skin
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Disturbances in components in the p53/MDM2/IGF-1R network may cause IGF-1R upregulation and growth advantage for the cancer cell
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