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However, the metabolic activation and protein adduct formation, also in mitochondria, are only marginally lower in rats compared to mice but there was no relevant mitochondrial dysfunction and oxidant stress in rats [124]

It affects one of the main links in the pigment formation process it reduces the production of melanin, whose excessive accumulation in the upper layers of the skin is seen in the form of pigmentation spots

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All preclinical research must be conducted with oversight from the appropriate Institutional Animal Care and Use Committee (IACUC) following the guidelines of the Animal Welfare Act (AWA)