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Participants were randomly assigned to receive either a 1.2 mg, 1.8 mg or 2.4 mg dose of ecnoglutide or a placebo

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Ex-4 significantly reduces neuroinflammation by converting proinflammatory M1 microglia into anti-inflammatory M2 microglia both in vitro and in vivo through the rescue of the expression of Arf and Rho GAP adapter protein 3 (ARAP3)