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Upon bile acid activation, hepatic FXR induces expression of small heterodimer partner (SHP), which suppresses CYP7A1 and CYP8B1 gene transcription, thereby reducing bile acid synthesis (68)

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Results May Vary: Individual weight loss results vary based on factors including age, baseline weight, consistency of medication adherence, diet and exercise changes, genetic factors, current medications, underlying health conditions, and other individual variables

Archived from the original on August 14, 2012