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29 Clinical trials assessing the efficacy of LOLA showed that it is at least comparable (sometimes superior) to other interventions (such as lactulose or oral antibiotics), in addition to being well-tolerated and associated with improvement in quality of life
Research into 5-Amino-1MQ has been conducted primarily in preclinical (animal and cellular) models, and it has not been approved by the MHRA, NICE, or any major regulatory authority for human therapeutic use
Thus, there is also no evidence for apoptosis switching to secondary necrosis during APAP hepatotoxicity
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