p = 0.60) ( In terms of safety, gastrointestinal adverse effectsparticularly nauseawere common across both sexes, but women reported higher rates of intolerance, which may lead to treatment discontinuation ( The reduction in MACE with SGLT-2 inhibitors appears to be less consistent in women with type 2 diabetes than in men, while GLP-1 receptor agonists provide similar cardiovascular benefits across sexes
Pooled data from these three trials showed that rates of HF hospitalization were not significantly different between DPP-4i and placebo, suggesting that the effect may not be a class effect [100, 101]
It has been hypothesized by research teams examining melanocortin receptor activity, that MC3R may potentially modulate the actions of other melanocortin receptors in this area
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