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Betaine synergistically enhances obesity and its metabolic complications through various targets via the AMPK-mitochondrial axis, SIRT1/SREBP-1/PPAR signaling, inhibition of inflammation, and the microbiota-SCFA-epigenetic cascade, providing a mechanistic basis for its clinical translation
This review discusses the biology of GLP-1 and its effects on cardiovascular risk factors, and it also elaborates on the positive direct cardiovascular outcomes of GLP-1 in animal studies
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