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Intracellularly, Gln can be converted by GLS1/GLS2 into glutamate, which is subsequently metabolized by GLUD or through transamination reactions to generate -KG that enters the TCA cycle, thereby providing anaplerotic substrates for oxidative metabolism and supporting mitochondrial OXPHOS activity (58)
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During times of energy scarcity (dieting), conserving fuel and minimizing maintenance costs is a survival advantage
Olivia Gilbert, MD, a cardiologist at Wake Forest University in Winston-Salem, North Carolina, believes improvements in cardiovascular risk factors have the biggest impact
