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In addition to weight loss, triple agonists are being studied for their effects on: Liver fat and NASH/MASLD (metabolic dysfunctionassociated steatotic liver disease)

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The paradigm builds on evidence that glutamate released by ketamine can reduce ligand ( 11 C-ABP688, 18 F-FPEB) binding to mGluR5 in two ways, through direct competition of glutamate and the PET ligand and by stimulating mGluR5 internalization [121]