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R UDPGA is synthesized in the cytosol from UDP-glucose by UDP-glucose dehydrogenase (requires NAD+), then transported into the ER lumen by the UGT-associated transporter

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Importantly, animals were singly housed to eliminate the exchange and cross-contamination of intestinal microbiomes, a factor that potentially biases studies with group-housed animals by minimizing microbiome variations for co-housed animals within a cohort

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