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Works cited GLP-1 and Appetite Control: How it Works and Why it's Effective - Westlake Dermatology, accessed April 22, 2025, Role of GLP-1 Receptor Agonists for Weight Loss - YouTube, accessed April 22, 2025, Weight Loss and Maintenance Related to the Mechanism of Action of Glucagon-Like Peptide 1 Receptor Agonists - PubMed Central, accessed April 22, 2025, Glucagon-like Receptor-1 agonists for obesity: Weight loss outcomes, tolerability, side effects, and risks, accessed April 22, 2025, How do Ozempic, Mounjaro, Wegovy, Zepbound compare for weight loss

Diana Mesa, RDN, LDN, CDCES, founder of En La Mesa Nutrition, agrees, adding that Berberine does have some similarities [to GLP-1 RA medications] in that it can trigger the pancreas to release insulin and helps make cells more sensitive to the effect of insulin, which is a characteristic similar to what Metformin [another prescription medication prescribed to treat type 2 diabetes and other off-label conditions] does. Still, she notes that its unclear whether or not Berberine has any appetite-suppressing effects like Ozempic and similar medications

Then, we added 100 nM cilostamide and then 100 nM retatrutide