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Fabbrini E, Serafini M, Colic Baric I, Hazen SL, Klein S
Additionally, stearic acid-grafted chitin oligosaccharide (COS-SA) micelles employ a unique dual-targeting mechanism: they utilize their high affinity for the Megalin receptor on renal tubular epithelial cells for active targeting, while simultaneously forming a protein crown by adsorbing human serum albumin (HSA), effectively avoiding phagocytic clearance by macrophages, thereby significantly enhancing renal accumulation efficiency [106]
SOD is essential in halting the proliferation of free radicals and in triggering the further antioxidant activity of CAT and GPx
It works by inhibiting the enzyme PDE5, which allows for greater nitric oxide activity, leading to relaxed blood vessels and improved circulation
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