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Tirzepatide improves physical function Researchers conducted a meta-analysis of six randomized controlled trials involving 4,536 participants and found that those treated with tirzepatide (Zepbound) had substantially better physical function than those receiving placebo
Given that both of these studies were in patients with OA of the knee (a load-bearing joint), it is likely that a significant proportion of the efficacy observed was due to the significant loss of body weight, reducing pathological joint loading
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