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Tirzepatide has a Other people who should not use tirzepatide include: Pregnant patients Patients with a history of: Severe gut disease Serious allergy to tirzepatide Pancreatitis Suicidal behavior or thoughts Interactions With Other Medications Blood levels of swallowed prescription or over-the-counter medications being taken at the same time as tirzepatide might be affected for two reasons: The stomach takes longer to empty