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Chronic ketamine exposure in rodent models (50 mg/kg daily for 8 weeks) leads to significant activation of microglial cells and elevated expression of proinflammatory cytokines, such as IL-6 and IL-1, which correlate with hippocampal neuronal damage (Yin et al., 2022)
These side effects are usually mild and tend to improve over time
Practices using automated billing workflows can trigger documentation reminders at the point of order, prompt staff to collect outstanding signatures before delivery, and flag claims that are missing required fields before they reach the payer
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