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The nervous system can become more sensitive over timea process often called central sensitizationwhich makes it easier for pain pathways to fire
Stopping is common: studies of real-world use suggest around half of users discontinue within a year, often because of cost, access or side effects
The suspension was incubated for 1 h at room temperature, before the membranes were isolated by centrifugation at 40,000 g for 30 min
Legry, V
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