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Concurrent medications Medications that affect gastrointestinal motility, such as opioids, anticholinergics, certain antidepressants, and proton pump inhibitors, can interact with semaglutide to intensify side effects
But their downsides are well-documented: high monthly costs, potential side effects such as nausea or gastrointestinal discomfort, and the need for injections
Recent research has discovered that metformin can inhibit FXR signaling by altering gut bacteria, leading to increased GLP-1 production and release in a way that does not depend on AMPK activation (Sun et al., 2018)
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