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For example, UK SmPCs for GLP-1 receptor agonists advise caution in patients with a history of pancreatitis or gallbladder disease, and include precautionary guidance regarding thyroid symptoms (such as a neck mass, difficulty swallowing, or hoarseness) that should be reported promptly

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If the intervals between shots are long enough, this can cause some weight regain, which can be very frustrating for patients, says Meghan Garcia-Webb, MD, a board-certified internal, lifestyle, and obesity medicine physician in private practice in Wellesley, Massachusetts