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Predicted physicochemical properties supported its hydrophobic character and oral bioavailability, suggesting it is a metabolically stable and BBB-permeable molecule [1]
Free L-histidine supplements (sometimes marketed for histamine regulation or joint health) could theoretically compete for copper binding in the circulation, though the tripeptide's chelation geometry gives it substantial kinetic advantage over free amino acid [1]
Barzegar S, Rezvani MR, Safa M, Amani A, Abbaspour A, Pourfathollah A, et al
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