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Spontaneous feeding-related monoamine changes in rostromedial hypothalamus of the obese Zucker rat: a microdialysis study
Onset of action: Clinical observations suggest noticeable effects within 3060 minutes of administration, making it practical for on-demand use
These include the development of next-generation glucagon-like peptide-1 receptor agonists (GLP1Ras), with their weight loss efficacy ranging from 12% to 15% for semaglutide and 20% for tirzepatide ( One salient concern regarding the use of GLP1Ras for older adults is their impact on skeletal health ( Given the rapid and increasing uptake of GLP1Ra-based therapies, coupled with the knowledge gap surrounding their impact on clinically relevant bone outcomes in older adults, we conducted an exploratory post hoc analysis of a pilot trial to explore the impact of 20 weeks of semaglutide use on bone density and turnover in older adults with overweight or obesity
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