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Ingredients like berberine and synephrine can interact with common medications or raise blood pressure
[7] [4] GRADE approach (2000) [edit] Along with Holger Jens Schnemann, Guyatt is the co-chair of the Grading of Recommendations Assessment, Development and Evaluation (GRADE) working group that began in the year 2000 as an informal collaboration of people with an interest in addressing the shortcomings of grading systems in clinical practice guidelines and systematic reviews
10.1016/S1474-4422(09)70126-7 340 Nieva-EchevarraB.GoicoecheaE.GuillnM
To protect patient safety, organizations must use insulated packaging that keeps medications within the labeled temperature range, ensure chain-of-custody, and manage risks like delays, temperature fluctuations, or improper handling in transit
