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These results suggest that GLP1R agonists in combination with a calcitonin receptor agonist, is able to show even larger decreases in body weight than typical GLP1R agonists, within a shorter time and with a more favourable side effect profile

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GLP-1RAs are FDA-approved drugs for obesity and T2DM and have been broadly studied as potential therapeutic agents in disorders characterized by alterations in reward processing pathways [10, 21,22,23, 27]