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While glutathione is a powerful antioxidant and theoretically could reduce oxidative stress in melanocytes, there is no robust clinical data showing that increasing dietary or supplemental glutathione can reliably prevent or reverse gray hair in humans. The bodys regulation of hair pigmentation is complex, he added, and once melanocytes lose their ability to produce pigment, antioxidants alone are unlikely to restore it

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specifically, the end-product, GSH, accumulates in the cell and acts as an inhibitor of -glutamylcysteine ligase activity, thereby preventing the overproduction of GSH 41 (Figure 2)