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Avoid high-fat foods, fried items, alcohol, and large portionsall worsen nausea and slow gastric emptying further

Neuro Endocrinol Lett 32:13340, PMID: 21552194 Kaddurah-Daouk R, Yuan P, Boyle SH, Matson W, Wang Z, Zeng ZB, Zhu H, Dougherty GG, Yao JK, Chen G, Guitart X, Carlson PJ, Neumeister A, Zarate C, Krishnan RR, Manji HK, Drevets W (2012) Cerebrospinal fluid metabolome in mood disorders-remission state has a unique metabolic profile

PKA directly phosphorylates sulfonylurea receptor 1 (SUR1), a regulatory subunit of voltage-dependent K + channels and KATP channels, increasing membrane depolarization and voltage-gated Ca 2+ channel activation

For those without prior GLP-1 sensitivity , starting at 0.5mg/week is more common