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Alterations in DDR If DNA damage is not repaired promptly, cellular senescence or apoptotic signals are activated, while abnormal activation of DDR maintains the viability of cancer cells, significantly inducing resistance to chemotherapeutic drugs and PARPis and affecting therapeutic efficacy [38]
Begin with a low dose: It is often best to start with 500 mg once daily for about a week
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Once released, GLP-1 sends signals to different parts of the body to help manage digestion and hunger
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