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Lipase activation leads to the release of fatty acids, which exacerbate pancreatic cell injury and accelerate inflammatory responses and cell death through multiple pathways ( 3.2 Dysregulation of glucose metabolism Dysregulation of glucose metabolism is another critical component of the metabolic disturbances observed in AP

"Efficacy and safety of co-administered once-weekly cagrilintide 24 mg with once-weekly semaglutide 24 mg in type 2 diabetes: a multicentre, randomised, double-blind, active-controlled, phase 2 trial"