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a study titled Blockade of mtDNA release ameliorates hepatic IR through avoiding cGAS-STING activation demonstrated that using a pharmacological inhibitor of Bax/Bak (which blocks mtDNA release from mitochondria) reduced liver injury and that adding a STING antagonist likewise protected the liver (51)
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Melatonin, known for its antioxidant properties, also modulates the Nrf2 pathway, enhancing the expression of heme oxygenase-1 (HO-1), which strengthens antioxidant defenses in DN (Negi et al., 2011a)
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