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We have previously shown that specific congeners of PBDEs (28, 47, 99, and 153) were predominant in VAT from obese individuals and that PBDEs 99, 28, and 47 were elevated in obese IR compared to obese IS

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This ROS-driven cascade converges on microvascular dysfunctioncharacterized by dysregulated vasodilation, compromised endothelial barrier function, and increased vascular fragilityultimately manifesting as mucosal erosions and hemorrhage, the hallmark features of PHG [373]