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While highly effective for weight loss and insulin resistance, side effects include nausea, diarrhea, constipation, and muscle loss
Factors influencing variation in basal metabolic rate include fat-free mass, fat mass, age, and circulating thyroxine but not sex, circulating leptin, or triiodothyronine
FDA approved a new higher dose of Wegovy 7.2 mg semaglutide injection in 2026 for weight loss and long-term weight maintenance in certain adult patients, reinforcing semaglutide's role in higher-intensity obesity treatment
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