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Results 18 out of the 93 references retrieved were selected for reviewing after applying the inclusion and exclusion criteria, 4 of them were discarded for being considered of low quality

Since there are known APOE -dependent differences in the gut microbiota in both humans and APOE-TR mice (Tran et al., 2019), L-carnitine metabolism could be impacted and, in turn, affect cerebrovascular function by disturbing normal L-carnitine shuttle function, particularly if other vulnerabilities are present