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Summary Interpretation The most defensible interpretation is that 5-Amino-1MQ is a small-molecule NNMT inhibitor that has been used in published preclinical research models without prominent severe acute toxicological signals described in the cited preclinical model reports under their specific tested conditions

For assessment of the nuclear cytoplasmic ratio of Nrf2 signal intensity, the nucleus was defined by Hoechst H-33342 staining

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