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In addition to acting on neuronal cells, GLP-1R agonists also exert effects on microglia and astrocytes through cAMP/PKA signaling pathway

However, some cutting-edge technologies like PROTACs (proteolysis-targeting chimeras), RNA interference, clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9-based genome editing, and artificial intelligence (AI)-based drug design, allow screening of therapeutics targeting almost all kinds of molecules, like proteins and epigenetic regulators