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The cause affects which treatment works best Medical history: Existing conditions, medications, and allergies that may interact Treatment goals: Whether the patient wants overall brightening, spot reduction, or both This step is what separates a safe, effective outcome from a disappointing or harmful one

Pretorius E, Venter C, Laubscher GJ, Lourens PJ, Steenkamp J, Kell DB

(2018) Glutathione for skin lightening: a regnant myth or evidence-based verity

In fact, transient overexpression of EAAT3 in hippocampal HT22 cells led to increased intracellular GSH levels in the presence of high glutamate concentrations, offering protection against oxidative glutamate toxicity [44, 45]