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Every vial ships with an HPLC purity trace (typically 99%), mass-spec identity confirmation, and endotoxin/heavy-metal screening on the batch

10.1016/S0140-6736(19)31271-1 Summary Keywords colorectal cancer, gastrointestinal cancer, GLP-1 receptor agonists, liver cancer, meta-analysis, obesity, oncological safety, pancreatic cancer Citation Wali AF, Rangraze I, Khan S, Mufti UB, El-Tanani M and Rizzo M (2026) Reassessing cancer risk with GLP-1 receptor agonists: a comprehensive meta-analysis of gastrointestinal malignancies

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In the one human trial that measured this directly (Sjdin et al., 2010), tesofensine increased 24-hour fat oxidation and raised nighttime energy expenditure by about 4.6%, but showed no significant effect on total 24-hour energy expenditure