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Overall, comparison of reported K p,brain, AUC u,brain /AUC u,plasma and K p,uu,brain values for released parent drug after prodrug dosing and drug itself (Table II) revealed significant improvement of brain delivery extent after administration of the following prodruds/derivatives: L-lysine-methotrexate conjugate in mice (117), lysine derivative of ketoprofen in rats (112), phenylalanine derivatives of ketoprofen in mice (79), venlafaxine-thiamine disulfide-glucose prodrug in mice (144), glucose prodrug of ibuprofen in mice (145), ascorbic acid derivatives of ibuprofen in mice (145, 147)

10.1007/s10142-010-0207-y Funct

10.1128/AAC.00001-13 Antimicrob