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While these supplements are generally safe, there are some groups that may be at higher risk for side-effects and should consult with a medical professional before starting any new supplements, including: Women who are pregnant or breastfeeding Infants and young children (unless otherwise noted) Those on prescription medications (for potential drug interactions) Those with chronic medical conditions Our Favorite Natural Supplements for Depression We trust the following products based on their quality and our clinical experience: Acetyl-L-Carnitine : Allergy Research Group Lithium : New Beginnings (liquid) & Biotics Research (capsules) Rhodiola : Herb Pharm (liquid) & Gaia Herbs (capsules) Chromium : Bio-Tech Pharmacal Vitamin B9 (Folate) : Jarrow Formulas (0.4mg or 1mg capsules) Vitamin B6 (P-5-P) : Klaire Labs & Designs for Health Vitamin B12 : Klaire Labs Vitamin B Complexes : Integrative Therapeutics & Thorne We are not endorsed by, directly affiliated with, maintained, authorized, or sponsored by any of these brands