In vitro hepatic models suggested that flavonoids and sulfur-containing compounds in garlic supplements might interfere with the activity of efflux drug transporters of the ATP-binding cassette (ABC) family, including P-glycoprotein, multidrug resistance protein (MRP), and breast cancer-resistance protein (BCRP), which function as ATP-dependent efflux pumps that actively regulate the excretion of a number of drugs limiting their systemic bioavailability
(More information) The results of randomized controlled trials suggested that garlic supplementation modestly improves serum lipid profiles in individuals with elevated serum cholesterol and reduces blood pressure in hypertensive subjects, at least in the short term
Elmorsy EA, Saber S, Hamad RS, Abdel-Reheim MA, El-Kott AF, AlShehri MA, et al
796 Proteomic analysis based on tandem mass tag showed that GSH metabolic pathway was downregulated during myocardial ischemia, especially GPX4 in the early and middle stages of myocardial infarction