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In the mouse xenograft model of human breast cancer MCF-7 cells, BZ reduced the effectiveness of TAM in the treatment of breast cancer and the concentration of endoxifen and 4-OH-tamoxifen in tumor-bearing mice (Li et al., 2019)
In published in vitro and preclinical research, IGF-1 LR3 has been studied in connection with binding to the IGF-1 receptor (IGF-1R) and reduced affinity for IGF-binding proteins (IGFBPs), and with downstream signaling pathways including PI3K/Akt and MAPK/ERK
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Further work is needed to assess the most effective dosing regimen to target the NRF2-GSH axis in the context of allergic asthma
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