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Limitations of Clinical Trial Data One important point is that clinical trials are designed to find common side effects, not rare ones

Cardiovascular effects There are isolated reports of berberine affecting heart rhythm, though evidence is limited

Third, the vial may be compromised

This effect may result from the promotion of healthy blood flow and oxygen supply to muscles along with the support of cellular metabolism [9].* Exercise is associated with an increased production of ROS that can promote tissue changes that support muscle adaptation to exercise, but that can also contribute to muscle damage and soreness [1012]