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This may result from accelerated muscle growth placing stress on joint structures (Velloso, Growth Hormone & IGF Research )

If symptoms are bothersome, remain at this dose for another week before increasing

The GLP-1RAs-associated weight loss is thought to be achieved through a variety of mechanisms, including the delayed gastric emptying, increased satiety, increased resting energy expenditure, as well as the direct influence of the appetite center of the brain (175)