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APAP overdose leads to excessive generation of the highly reactive metabolite n-acetyl-p-benzoquinone imine (NAPQI), which depletes glutathione (GSH), increases oxidative stress, and causes mitochondrial dysfunction, finally triggering immune response-mediated hepatotoxicity and massive hepatocytes necrosis [15, 16]

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Cardiovascular safety, long-term noncardiovascular safety, and efficacy of sodium-glucose cotransporter 2 inhibitors in patients with type 2 diabetes mellitus: a systemic review and meta-analysis with trial sequential analysis