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Sulforaphane (SFN), a sulfur-containing isothiocyanate compound naturally found in cruciferous vegetables (i.e., cauliflower, broccoli, brussels sprouts, and cabbage) could enhance Nrf2 activity

Glutathione is not only directly involved in scavenging free radicals, but also regulates foreign antioxidants (such as vitamin C and vitamin E)

If side effects are troublesome, the SmPC advises that dose escalation can be delayed by an additional 4 weeks to allow better tolerance

Antioxidants play a pivotal role in neutralizing ROS and preventing oxidative damage to melanocytes, which is crucial for maintaining skin pigmentation and reducing the risk of disorders like vitiligo or melanoma (Table 2)